Research / Testosterone & Cardiovascular Risk / Article
Testosterone replacement therapy and cardiovascular disease.
Jeremy M Auerbach, Mohit Khera
MODERATE
Evidence strength
Derived from study design, sample signals, and bias cues in available metadata — not a mystery score.
HIGH
Clinical relevance
How directly the endpoints and population map to hormone-medicine practice.
MODERATE
Risk / caveats
Lower meter values mean higher remaining bias or confounding concern.
Key takeaway
Testosterone therapy should be individualized with cardiovascular risk assessment and monitoring rather than categorically avoided.
Study at a glance
Design
Journal Article
Journal / year
International journal of impotence research · November 2022
Population
Humans
Endpoint
Testosterone therapy should be individualized with cardiovascular risk assessmen
Abstract
The use of testosterone therapy has a complex history of apprehension and questions regarding its safety. Despite an eventual consensus that testosterone therapy was safe and effective, several studies relating to cardiovascular risks emerged in the last decade, rekindling skepticism regarding the safety of testosterone therapy. Given the utility of testosterone therapy in treating the symptoms of hypogonadism, it remains crucial to closely examine the safety of testosterone therapy. The present article synthesizes the current evidence regarding cardiovascular risks that may be associated with testosterone therapy, the potential mechanisms regarding testosterone's efficacy, and future directions in evaluating the safety of its use.