Evidence with Confidence
Don't just get an answer.Know which evidence matters.
Ask a clinical question. RAGMD finds the studies that matter, shows which evidence should drive the conclusion, explains disagreement, and tells you how confident to be.
Example: Testosterone Therapy
Does testosterone replacement increase cardiovascular risk?
Large randomized evidence does not show increased major cardiovascular events with appropriately indicated TRT.
Major cardiovascular events (MACE)
Why it matters
Largest direct randomized cardiovascular-safety trial addressing this question.
Live evidence preview
See what RAGMD delivers on a real clinical question
Does testosterone replacement increase cardiovascular risk?
Bottom line
Large randomized data (including TRAVERSE) do not show a significant increase in major adverse cardiovascular events with testosterone therapy in hypogonadal men over median follow-up of roughly three years. Older observational studies conflict, and absolute risk depends on baseline cardiovascular disease, formulation, and monitoring.
Testosterone replacement therapy and cardiovascular disease.
Validated effect estimates in the analyzed set include odds ratio 1.07; HR 1. Statistical significance is not the same as clinical importance.
Testosterone therapy should be individualized with cardiovascular risk assessment and monitoring rather than categorically avoided.
Evidence confidence
Evidence Confidence
HighMultiple high-quality studies directly address this question, with generally consistent findings.
Published evidence synthesis
Explore the full evidence →Topic discovery
Clinical areas RAGMD maintains
Explore maintained evidence by clinical domain — with question counts where published.
Men's Hormone Health
Testosterone therapy, estradiol in men, monitoring controversies, and TRT safety questions.
12 maintained questions
Mixed confidence across questions
Men's Sexual Health
Erectile dysfunction, PDE5 inhibitors, testosterone and sexual function, and premature ejaculation evidence.
10 maintained questions
Mostly high-confidence questions
Menopause & Women's Health
HRT safety, perimenopause, vasomotor symptoms, GSM, bone health, and women's hormone therapy.
22 maintained questions
Mixed confidence across questions
Thyroid
Hypothyroidism treatment targets, combination therapy, desiccated thyroid, and thyroid-metabolic questions.
6 maintained questions
Mixed confidence across questions
Cardiometabolic Risk
Lipids, statins, ApoB, blood pressure, and cardiovascular prevention evidence.
10 maintained questions
Mixed confidence across questions
Weight, GLP-1 & Metabolic Therapy
GLP-1 outcomes, muscle preservation, weight regain, and incretin safety questions.
7 maintained questions
Mixed confidence across questions
Longevity & Preventive Medicine
Supplementation, aging-related hormones, and preventive medicine evidence reviews.
4 maintained questions
Mixed confidence across questions
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How it works
From clinical question to source-verified synthesis
Ask a question. RAGMD finds relevant evidence, determines which studies matter most, surfaces credible disagreement, and explains Evidence Confidence.
See How It WorksPubMed AI
Search medical literature with PubMed-linked AI
Not ChatGPT with guessed citations. RAGMD searches your library and PubMed, weighs which trials matter, and returns PMID-linked evidence you can share.
PubMed AI for physiciansHormone & metabolic medicine for clinicians — not RadMD radiology prior auth.