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Keep symptoms, tests, interventions, and responses connected to dates and sources.
Timeline editing · In previewRAGMD · Clinical evidence in context
The whole journey.
The evidence behind it.
A clinical question deserves more than an isolated answer. Explore the evidence, inspect where it applies, and bring the story over time into view.
Workspace preview · Synthetic cases only
Traceable sourcesVisible uncertaintyClinician-led review
Case reviewIllustrative preview
The journey
Synthetic follow-up
AdultAge not entered
- Symptoms reported
Baseline severity not recorded
- Initial intervention
Adherence needs clarification
- Limited improvement
Response reported at follow-up
Current question
DraftWhat needs reconsideration?
Clarify the change, compare possibilities, and identify what evidence would apply.
Information to resolve
Comparable outcome measure and treatment details are missing.
Population & applicabilityInspect
Alternatives & evidence gapsCompare
Follow-up & review historyRecord
Open the working previewNo diagnosis or recommendation generated. Preview entries are clinician authored.
Available today
Start with a clinical question.
Search evidence without entering patient information.
From question to review
A clearer view of the next question.
Evidence research is available now. The case workspace lets you explore the next experience with synthetic information.
Inspect the evidence
Explore published research. In the preview, attach sources and record applicability limits.
Evidence search · Available todayCompare the possibilities
Document alternatives, evidence for and against, and information still needed.
Clinician-authored comparison · In previewCarry the review forward
Create a brief, save a session baseline, inspect changes, and export your work.
Session versions & export · In previewInspect before you trust
Keep the reasoning open to review.
Source findings, patient context, and clinician decisions should remain distinct.
Explore our methodologyOriginal sourcesOpen the underlying research and assess support.
Applicability limitsRecord who was studied and what remains unknown.
Visible review statusA draft remains a draft until reviewed.
Live evidence preview
See what RAGMD delivers on a real clinical question
Does testosterone replacement increase cardiovascular risk?
Bottom line
Large randomized data (including TRAVERSE) do not show a significant increase in major adverse cardiovascular events with testosterone therapy in hypogonadal men over median follow-up of roughly three years. Older observational studies conflict, and absolute risk depends on baseline cardiovascular disease, formulation, and monitoring.
Pivotal
Testosterone replacement therapy and cardiovascular disease.
Validated effect estimates in the analyzed set include odds ratio 1.07; HR 1. Statistical significance is not the same as clinical importance.
Testosterone therapy should be individualized with cardiovascular risk assessment and monitoring rather than categorically avoided.
Evidence confidence
Evidence Confidence
HighLimitedModerateHigh
Multiple high-quality studies directly address this question, with generally consistent findings.
Published evidence synthesis
Explore the full evidence →Topic discovery
Clinical areas RAGMD maintains
Explore maintained evidence by clinical domain — with question counts where published.
Men's Hormone Health
Testosterone therapy, estradiol in men, monitoring controversies, and TRT safety questions.
12 maintained questions
Mixed confidence across questions
Men's Sexual Health
Erectile dysfunction, PDE5 inhibitors, testosterone and sexual function, and premature ejaculation evidence.
10 maintained questions
Mostly high-confidence questions
Menopause & Women's Health
HRT safety, perimenopause, vasomotor symptoms, GSM, bone health, and women's hormone therapy.
22 maintained questions
Mixed confidence across questions
Thyroid
Hypothyroidism treatment targets, combination therapy, desiccated thyroid, and thyroid-metabolic questions.
6 maintained questions
Mixed confidence across questions
Cardiometabolic Risk
Lipids, statins, ApoB, blood pressure, and cardiovascular prevention evidence.
10 maintained questions
Mixed confidence across questions
Weight, GLP-1 & Metabolic Therapy
GLP-1 outcomes, muscle preservation, weight regain, and incretin safety questions.
7 maintained questions
Mixed confidence across questions
Longevity & Preventive Medicine
Supplementation, aging-related hormones, and preventive medicine evidence reviews.
4 maintained questions
Mixed confidence across questions
Start with evidence. Explore the workspace.
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How it works
From clinical question to source-verified synthesis
Ask a question. RAGMD finds relevant evidence, determines which studies matter most, surfaces credible disagreement, and explains Evidence Confidence.
See How It WorksPubMed AI
Search medical literature with PubMed-linked AI
RAGMD searches your library and PubMed, weighs which trials matter, and returns PMID-linked evidence you can share.
PubMed AI for physiciansHormone & metabolic medicine for clinicians — not RadMD radiology prior auth.