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RAGMD · Evidence with Confidence
Search published medical research, trace the original studies and see where findings agree, conflict or remain uncertain. Explore freely. Sign in when you want to save your evidence.
Public research discovery is open. Medical summaries may be automated or awaiting independent clinical review; inspect original sources before relying on conclusions.
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Example research question
Does menopausal hormone therapy improve sleep quality?
Evidence summary
Direct answer, limitations and remaining uncertainty
Key studies
Source-level citations and study design
Conflicting findings
Understand why outcomes can differ
Research implications
Questions worth investigating further
Illustrative navigation, not a medical conclusion or clinical approval.
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Live evidence preview
Bottom line
Large randomized data (including TRAVERSE) do not show a significant increase in major adverse cardiovascular events with testosterone therapy in hypogonadal men over median follow-up of roughly three years. Older observational studies conflict, and absolute risk depends on baseline cardiovascular disease, formulation, and monitoring.
Testosterone replacement therapy and cardiovascular disease.
Validated effect estimates in the analyzed set include odds ratio 1.07; HR 1. Statistical significance is not the same as clinical importance.
Testosterone therapy should be individualized with cardiovascular risk assessment and monitoring rather than categorically avoided.
Evidence confidence
Evidence Confidence
HighMultiple high-quality studies directly address this question, with generally consistent findings.
Published evidence synthesis
Explore the full evidence →Topic discovery
Explore maintained evidence by clinical domain — with question counts where published.
Testosterone therapy, estradiol in men, monitoring controversies, and TRT safety questions.
12 maintained questions
Mixed confidence across questions
Erectile dysfunction, PDE5 inhibitors, testosterone and sexual function, and premature ejaculation evidence.
10 maintained questions
Mostly high-confidence questions
HRT safety, perimenopause, vasomotor symptoms, GSM, bone health, and women's hormone therapy.
22 maintained questions
Mixed confidence across questions
Hypothyroidism treatment targets, combination therapy, desiccated thyroid, and thyroid-metabolic questions.
6 maintained questions
Mixed confidence across questions
Lipids, statins, ApoB, blood pressure, and cardiovascular prevention evidence.
10 maintained questions
Mixed confidence across questions
GLP-1 outcomes, muscle preservation, weight regain, and incretin safety questions.
7 maintained questions
Mixed confidence across questions
Supplementation, aging-related hormones, and preventive medicine evidence reviews.
4 maintained questions
Mixed confidence across questions
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How it works
Ask a question. RAGMD finds relevant evidence, determines which studies matter most, surfaces credible disagreement, and explains Evidence Confidence.
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RAGMD searches your library and PubMed, weighs which trials matter, and returns PMID-linked evidence you can share.
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