Evidence
Explore the Evidence
Evidence organized around the questions clinicians actually ask.
Evidence sourced from PubMed and curated medical literature.
71 published evidence questions.
Evidence questions
Grouped by clinical focus area so you can see coverage at a glance.
Men's Hormone Health
12 evidence questions
Do transdermal and injectable testosterone differ
Do transdermal and injectable testosterone differ in safety or efficacy?
Moderate confidence14 curated studies
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How should low testosterone be diagnosed
How should low testosterone be diagnosed in symptomatic men?
High confidence14 curated studies
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Does testosterone therapy improve depression or
Does testosterone therapy improve depression or low mood in hypogonadal men?
Moderate confidence10 curated studies
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Does testosterone therapy worsen obstructive sleep
Does testosterone therapy worsen obstructive sleep apnea?
Moderate confidence14 curated studies
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Do aromatase inhibitors in men increase
Do aromatase inhibitors in men increase bone loss risk?
Moderate confidence14 curated studies
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Does estradiol level affect symptoms and
Does estradiol level affect symptoms and bone health in men on testosterone therapy?
Moderate confidence14 curated studies
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Does testosterone therapy reduce cardiovascular events
Does testosterone therapy reduce cardiovascular events?
High confidence10 curated studies
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Does testosterone therapy increase venous thromboembolism
Does testosterone therapy increase venous thromboembolism risk?
Moderate confidence14 curated studies
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Does testosterone therapy suppress fertility in
Does testosterone therapy suppress fertility in men?
High confidence14 curated studies
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Does testosterone therapy increase hematocrit and
Does testosterone therapy increase hematocrit and polycythemia risk?
High confidence14 curated studies
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Does testosterone therapy increase prostate cancer
Does testosterone therapy increase prostate cancer risk?
Moderate confidence14 curated studies
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Does testosterone replacement increase cardiovascular risk
Does testosterone replacement increase cardiovascular risk?
High confidence11 curated studies
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Men's Sexual Health
10 evidence questions
Do sildenafil, tadalafil, and vardenafil differ
Do sildenafil, tadalafil, and vardenafil differ in effectiveness for erectile dysfunction?
High confidence12 curated studies
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What are the common side effects
What are the common side effects of PDE5 inhibitors?
High confidence12 curated studies
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What treatments are effective for premature
What treatments are effective for premature ejaculation?
High confidence12 curated studies
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What options exist for men who
What options exist for men who do not respond to PDE5 inhibitors?
Moderate confidence12 curated studies
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Does testosterone therapy improve erectile function
Does testosterone therapy improve erectile function in hypogonadal men?
High confidence14 curated studies
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Is erectile dysfunction a marker of
Is erectile dysfunction a marker of future cardiovascular disease?
High confidence12 curated studies
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Why are PDE5 inhibitors contraindicated with
Why are PDE5 inhibitors contraindicated with nitrates?
High confidence12 curated studies
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Are PDE5 inhibitors safe for cardiovascular
Are PDE5 inhibitors safe for cardiovascular disease in men with erectile dysfunction?
High confidence12 curated studies
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Is daily low-dose tadalafil better than
Is daily low-dose tadalafil better than on-demand dosing for erectile dysfunction?
High confidence12 curated studies
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How effective are PDE5 inhibitors for
How effective are PDE5 inhibitors for erectile dysfunction?
High confidence12 curated studies
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Menopause & Women's Health
22 evidence questions
Can GLP-1 therapy be combined safely
Can GLP-1 therapy be combined safely with hormone optimization regimens?
Limited confidence14 curated studies
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Is transdermal estrogen preferred over oral
Is transdermal estrogen preferred over oral estrogen in menopause?
High confidence14 curated studies
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Does menopause cause weight gain and
Does menopause cause weight gain and can hormone therapy help?
Moderate confidence10 curated studies
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Is menopause associated with cognitive changes
Is menopause associated with cognitive changes or brain fog?
Limited confidence10 curated studies
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Does hormone therapy help depression or
Does hormone therapy help depression or anxiety during perimenopause?
Moderate confidence10 curated studies
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How long should menopausal hormone therapy
How long should menopausal hormone therapy be continued?
Moderate confidence14 curated studies
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Should women with early surgical menopause
Should women with early surgical menopause receive hormone therapy?
High confidence14 curated studies
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Does testosterone therapy improve sexual function
Does testosterone therapy improve sexual function in postmenopausal women?
Moderate confidence14 curated studies
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What is the evidence for treating
What is the evidence for treating genitourinary syndrome of menopause?
High confidence14 curated studies
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Does hormone therapy improve sleep disturbance
Does hormone therapy improve sleep disturbance in menopause?
Moderate confidence10 curated studies
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Does menopausal hormone therapy prevent osteoporosis
Does menopausal hormone therapy prevent osteoporosis and fractures?
High confidence14 curated studies
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Is fezolinetant effective for menopausal hot
Is fezolinetant effective for menopausal hot flashes?
High confidence10 curated studies
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What therapies are most effective for
What therapies are most effective for vasomotor symptoms in perimenopause?
High confidence10 curated studies
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What is the evidence for hormone
What is the evidence for hormone and metabolic therapy in PCOS?
High confidence14 curated studies
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Does hormone therapy prevent cognitive decline
Does hormone therapy prevent cognitive decline or dementia?
Moderate confidence14 curated studies
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Does low-dose vaginal estrogen carry significant
Does low-dose vaginal estrogen carry significant systemic risks?
High confidence14 curated studies
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Are bioidentical hormone preparations safer or
Are bioidentical hormone preparations safer or more effective than conventional HRT?
Moderate confidence14 curated studies
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Is progestogen required to protect the
Is progestogen required to protect the endometrium with estrogen therapy?
High confidence14 curated studies
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Is there a critical timing window
Is there a critical timing window for cardiovascular benefit from HRT?
Moderate confidence14 curated studies
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Does hormone replacement therapy increase venous
Does hormone replacement therapy increase venous thromboembolism risk?
High confidence14 curated studies
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Does hormone replacement therapy reduce cardiovascular
Does hormone replacement therapy reduce cardiovascular risk in early menopause?
Moderate confidence14 curated studies
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Does hormone replacement therapy increase breast
Does hormone replacement therapy increase breast cancer risk?
High confidence10 curated studies
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Thyroid
6 evidence questions
What factors interfere with levothyroxine absorption
What factors interfere with levothyroxine absorption?
High confidence11 curated studies
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Does treated hypothyroidism fully explain difficulty
Does treated hypothyroidism fully explain difficulty losing weight?
Moderate confidence11 curated studies
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What TSH target is appropriate for
What TSH target is appropriate for treated hypothyroidism?
Moderate confidence11 curated studies
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Is desiccated thyroid extract superior to
Is desiccated thyroid extract superior to levothyroxine for hypothyroidism?
High confidence11 curated studies
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Should subclinical hypothyroidism be treated with
Should subclinical hypothyroidism be treated with levothyroxine?
High confidence11 curated studies
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Does combination T3/T4 therapy improve symptoms
Does combination T3/T4 therapy improve symptoms versus levothyroxine alone?
Limited confidence11 curated studies
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Cardiometabolic Risk
10 evidence questions
Should coronary artery calcium scoring guide
Should coronary artery calcium scoring guide statin decisions?
High confidence11 curated studies
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Should aspirin be used for primary
Should aspirin be used for primary cardiovascular prevention?
High confidence14 curated studies
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Do omega-3 supplements prevent cardiovascular disease
Do omega-3 supplements prevent cardiovascular disease in the general population?
Moderate confidence14 curated studies
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Do therapies that raise HDL reduce
Do therapies that raise HDL reduce cardiovascular events?
High confidence11 curated studies
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Does testosterone therapy affect blood pressure
Does testosterone therapy affect blood pressure?
Limited confidence14 curated studies
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Can hormone therapy help insulin resistance
Can hormone therapy help insulin resistance in peri- and postmenopausal women?
Moderate confidence14 curated studies
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Does hormone therapy improve metabolic syndrome
Does hormone therapy improve metabolic syndrome markers?
Moderate confidence14 curated studies
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Does elevated lipoprotein(a) independently increase cardiovascular
Does elevated lipoprotein(a) independently increase cardiovascular risk?
High confidence11 curated studies
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Should adults take statins for primary
Should adults take statins for primary cardiovascular prevention?
High confidence12 curated studies
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Is ApoB more useful than LDL-C
Is ApoB more useful than LDL-C for cardiovascular risk prediction?
High confidence14 curated studies
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Weight, GLP-1 & Metabolic Therapy
7 evidence questions
Can resistance training and protein intake
Can resistance training and protein intake preserve muscle during GLP-1 weight loss?
Limited confidence11 curated studies
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How does tirzepatide compare with semaglutide
How does tirzepatide compare with semaglutide for weight loss?
High confidence11 curated studies
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Do GLP-1 drugs increase thyroid cancer
Do GLP-1 drugs increase thyroid cancer risk in humans?
Moderate confidence11 curated studies
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Do GLP-1 agonists increase pancreatitis risk
Do GLP-1 agonists increase pancreatitis risk?
Moderate confidence11 curated studies
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Do patients regain weight after stopping
Do patients regain weight after stopping GLP-1 therapy?
High confidence11 curated studies
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Do GLP-1 receptor agonists reduce major
Do GLP-1 receptor agonists reduce major cardiovascular events?
High confidence14 curated studies
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Does GLP-1 treatment cause meaningful muscle
Does GLP-1 treatment cause meaningful muscle loss?
High confidence11 curated studies
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Longevity & Preventive Medicine
4 evidence questions
When is growth hormone replacement appropriate
When is growth hormone replacement appropriate in adults?
High confidence11 curated studies
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Does DHEA supplementation improve health outcomes
Does DHEA supplementation improve health outcomes in aging adults?
Limited confidence11 curated studies
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Does magnesium supplementation improve metabolic health
Does magnesium supplementation improve metabolic health markers?
Moderate confidence11 curated studies
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Does vitamin D supplementation reduce mortality
Does vitamin D supplementation reduce mortality or major disease?
High confidence11 curated studies
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RAGMD connects clinical questions to published studies, evidence synthesis, and expert teaching — so you can see where research agrees, where it conflicts, and what remains uncertain.
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