Research library
Evidence sourced from PubMed and curated medical literature. Browse published study records — start with a clinical question on the Evidence page for synthesis.
Explore evidence questionsBACKGROUND: Menopausal hormone therapy (MHT) is widely prescribed for alleviating menopausal symptoms. Prior studies have mainly focused on individual hormone therapy formulations.
PURPOSE OF REVIEW: Perimenopause is a period of hormonal volatility associated with clinically relevant changes in metabolism and cardiometabolic risk. In addition to vasomotor symptoms, sleep disruption, and changes in body composition, the transition from the late reproductive years to early postmenopause is characterized by physiologic alterations that may precede formal diagnostic thresholds for metabolic syndrome.
This meta-analysis aimed to clarify the association between glucagon-like peptide-1 receptor agonists, used for weight management in obesity, and the risks of pancreatitis and pancreatic cancer. We systematically searched PubMed, Web of Science, Embase, the Cochrane Library, and Scopus through June 15, 2026, for clinical studies conducted in obese populations.
T helper 17 (Th17) cells are heterogeneous: homeostatic Th17 (Th17 Hom ) cells maintain tissue homeostasis, and pro-inflammatory Th17 (Th17 Inf ) cells drive autoimmune inflammation. IL-23 drives Th17 Inf , but the signals that maintain Th17 Hom remain unclear.
Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and psychological morbidity, and sexual health concerns.
Background/Objectives : Incretin-based pharmacotherapies are the most effective non-surgical treatments for obesity to date, yet 85% of patients discontinue within the second year of real-world use. No established framework exists for managing this post-cessation transition.
The enterolimbic axis represents a novel conceptual framework which redefines gut-brain interactions by integrating gastrointestinal physiology, microbiota, incretin signaling, and affective regulation. Recent advances demonstrate that gut-derived signals influence reward processing, eating behavior, and emotional states through hierarchical circuits linking the enteric nervous system, vagal afferents, and limbic regions.
Polycystic ovary syndrome (PCOS) is a common endocrine condition that presents with reproductive, metabolic, and cardiometabolic disturbances. Altered adipokine activity, including changes in circulating leptin, a macromolecule, may contribute to its clinical features.
