A curse to last 10,000 years. A nuclear-waste dump needs a 'keep out' sign with a long half-life.

U.S. news & world report · August 2002 · James M Pethokoukis

What this study found

This study examines A curse to last 10,000 years. A nuclear-waste dump needs a 'keep out' sign with a long half-life. Editorial review is required before publishing clinical takeaways.

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Landmark study

Why this trial matters

WHI estrogen plus progestin

How RAGMD uses this study

Clinical questions this paper informs

Synthesis lives on the evidence question — this page shows where the study sits in that analysis.

Core study

Does hormone replacement therapy increase breast cancer risk?

Combined estrogen-progestin therapy is associated with a small increased breast cancer risk in WHI and observational data. Estrogen-alone in hysterectomized women showed lower risk in WHI, but interpretation depends on regimen, duration, and individual risk factors.

Open evidence analysis

Core study

Is progestogen required to protect the endometrium with estrogen therapy?

Systemic estrogen in women with a uterus requires adequate progestogen exposure to prevent endometrial hyperplasia. Micronized progesterone and progestins differ in metabolic and VTE profiles.

Open evidence analysis

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