Research · PMID 19619483 · Landmark study
Reviewed by Neal Rouzier, MD, Preventive Medicine · Sep 2026
Determination of dissociation constants in living zebrafish embryos with single wavelength fluorescence cross-correlation spectroscopy.
Biophysical journal · July 2009 · Xianke Shi, Yong Hwee Foo, Thankiah Sudhaharan, Shang-Wei Chong, Vladimir Korzh, et al.
What this study found
The quantification of biological interactions is very important in life sciences. Here we report for the first time, to our knowledge, the determination of a biomolecular dissociation constant (K(D)) in living zebrafish embryos at physiological protein expression levels.
Why this trial matters
Emerging Risk Factors Collaboration ApoB
How RAGMD uses this study
Clinical questions this paper informs
Synthesis lives on the evidence question — this page shows where the study sits in that analysis.
Core study
Is ApoB more useful than LDL-C for cardiovascular risk prediction?
Prospective cohorts and meta-analyses suggest ApoB may capture atherogenic particle burden better than LDL-C alone, particularly when triglycerides are elevated or LDL particles are discordant with LDL-C.
Open evidence analysis