Research · PMID 41798477
Reviewed by Neal Rouzier, MD, Preventive Medicine · Sep 2026
Psychiatric and Cognitive Effects of Testosterone Therapy in Adult Men: A Systematic Review of Clinical Evidence and Mechanistic Insights.
Cureus · February 2026 · Luis M Canal de Velasco, José Emiliano González Flores, Laura Vargas, Jose Luis Morales Arteaga
What this study found
Testosterone plays a critical role in male physical and psychological health, influencing not only reproductive and metabolic functions but also mood, cognition, and overall mental well-being. Age-related testosterone decline has been associated with depressive symptoms, cognitive impairment, and reduced quality of life.
How RAGMD uses this study
Clinical questions this paper informs
Synthesis lives on the evidence question — this page shows where the study sits in that analysis.
Primary study
Does testosterone therapy improve depression or low mood in hypogonadal men?
Some randomized trials and meta-analyses show modest improvements in depressive symptoms among men with low testosterone, but effects are heterogeneous and not a substitute for standard psychiatric evaluation when major depression is present.
Open evidence analysis