Research · PMID 42081070
Reviewed by Neal Rouzier, MD, Preventive Medicine · Sep 2026
Once-weekly somapacitan vs. daily norditropin in GHD: a systematic review and meta-analysis of efficacy and safety in children and adults.
Endocrine · May 2026 · Sarah Azhar, Mohammad Daniyal, Roshni Riaz Memon, Hamza Sajid, Nad E Ali Yousfani, et al.
What this study found
Once-weekly somapacitan demonstrates comparable efficacy and safety to daily Norditropin while offering greater convenience that may improve treatment adherence. These findings support somapacitan as a promising therapeutic option for patients with GHD, although long-term real-world studies are needed to confirm susta…
How RAGMD uses this study
Clinical questions this paper informs
Synthesis lives on the evidence question — this page shows where the study sits in that analysis.
Core study
When is growth hormone replacement appropriate in adults?
Growth hormone replacement is evidence-supported for adults with confirmed GH deficiency from pituitary disease, improving body composition and quality of life. Use in healthy aging or performance enhancement lacks safety and efficacy evidence.
Open evidence analysisSupporting literature
Does vitamin D supplementation reduce mortality or major disease?
Meta-analyses show vitamin D supplementation does not significantly reduce all-cause mortality in unselected populations. Targeted repletion may benefit those with documented deficiency.
Open evidence analysisSupporting literature
Does magnesium supplementation improve metabolic health markers?
Trials in deficient or at-risk individuals show modest improvements in some glycemic and blood pressure markers, but routine supplementation for metabolic disease prevention is not strongly supported in general populations.
Open evidence analysisSupporting literature
Does DHEA supplementation improve health outcomes in aging adults?
DHEA raises circulating androgens and estrogens modestly but lacks robust outcome trial evidence for cardiovascular, cognitive, or mortality benefit in healthy aging adults without documented deficiency.
Open evidence analysis