Effect of Metformin Monotherapy on Circulating Leptin Levels in Polycystic Ovary Syndrome: A Systematic Review and Bayesian Meta-analysis of Randomized Placebo Controlled Trials.

Annals of African medicine · July 2026 · Neha Gangane, Prateek Banerjee, Priyanka Rai, Swati Swati, Vineeta Vineeta, et al.

What this study found

Polycystic ovary syndrome (PCOS) is a common endocrine condition that presents with reproductive, metabolic, and cardiometabolic disturbances. Altered adipokine activity, including changes in circulating leptin, a macromolecule, may contribute to its clinical features.

Open on PubMed DOI

systematic_review

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Clinical questions this paper informs

Synthesis lives on the evidence question — this page shows where the study sits in that analysis.

Primary study

What is the evidence for hormone and metabolic therapy in PCOS?

PCOS management prioritizes lifestyle intervention, cycle regulation, and treatment of hyperandrogenism and metabolic risk. Metformin and hormonal contraceptives have evidence for specific endpoints; individualized plans depend on fertility goals.

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