Topics / Longevity & Preventive Medicine
Focus area
Longevity & Preventive Medicine
Evidence you can trust. Clinical questions you care about.
Supplementation, aging-related hormones, and preventive medicine evidence reviews.
Reviewed by Neal Rouzier, MD, Preventive Medicine · Aug 2026
4 published deep analyses
Featured evidence questions
Top clinical questions
High-priority clinical questions with structured evidence analysis in this focus area.
When is growth hormone replacement appropriate
When is growth hormone replacement appropriate in adults?
Growth hormone replacement is evidence-supported for adults with confirmed GH deficiency from pituitary disease, improving body composition and quality of life. Use in healthy aging or performance enhancement lacks safety and efficacy evidence.
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Does vitamin D supplementation reduce mortality
Does vitamin D supplementation reduce mortality or major disease?
Meta-analyses show vitamin D supplementation does not significantly reduce all-cause mortality in unselected populations. Targeted repletion may benefit those with documented deficiency.
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Does magnesium supplementation improve metabolic health
Does magnesium supplementation improve metabolic health markers?
Trials in deficient or at-risk individuals show modest improvements in some glycemic and blood pressure markers, but routine supplementation for metabolic disease prevention is not strongly supported in general populations.
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Does DHEA supplementation improve health outcomes
Does DHEA supplementation improve health outcomes in aging adults?
DHEA raises circulating androgens and estrogens modestly but lacks robust outcome trial evidence for cardiovascular, cognitive, or mortality benefit in healthy aging adults without documented deficiency.
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Published deep analyses
Evidence map
All published structured analyses in this focus area, with core studies and explainable confidence.
When is growth hormone replacement appropriate
When is growth hormone replacement appropriate in adults?
Growth hormone replacement is evidence-supported for adults with confirmed GH deficiency from pituitary disease, improving body composition and quality of life. Use in healthy aging or performance enhancement lacks safety and efficacy evidence.
Open deep analysis →
Does vitamin D supplementation reduce mortality
Does vitamin D supplementation reduce mortality or major disease?
Meta-analyses show vitamin D supplementation does not significantly reduce all-cause mortality in unselected populations. Targeted repletion may benefit those with documented deficiency.
Open deep analysis →
Does magnesium supplementation improve metabolic health
Does magnesium supplementation improve metabolic health markers?
Trials in deficient or at-risk individuals show modest improvements in some glycemic and blood pressure markers, but routine supplementation for metabolic disease prevention is not strongly supported in general populations.
Open deep analysis →
Does DHEA supplementation improve health outcomes
Does DHEA supplementation improve health outcomes in aging adults?
DHEA raises circulating androgens and estrogens modestly but lacks robust outcome trial evidence for cardiovascular, cognitive, or mortality benefit in healthy aging adults without documented deficiency.
Open deep analysis →
Latest evidence
Recent core studies
Recently published studies linked to evidence analyses in this focus area.
Nutrients · 2026
Comprehensive Effects of Magnesium Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Dose-Response Meta-Analysis.
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BMC nutrition · 2026
Oral magnesium supplements and insulin resistance in individuals with diabetes and pre-diabetes: an updated systematic review and meta-analysis of randomized controlled trials.
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Endocrine · 2026
Once-weekly somapacitan vs. daily norditropin in GHD: a systematic review and meta-analysis of efficacy and safety in children and adults.
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Related topics
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